Indeed, altered EEG rhythms, including an increase in gamma power, have been observed in Shank3-mutant mice (Han et al., 2013; Wang et al., 2016; Dhamne et al., 2017; Ingiosi et al., 2019; Yoo et al., 2019) as well as in SHANK3-related ASD and PMS (Soorya et al., 2013; Holder and Quach, 2016). The gene discussed is SHANK3; the disease is premenstrual tension.