Given the well-known association between SHANK3 and various neurodevelopmental disorders, including ASD, PMS and schizophrenia (Phelan and McDermid, 2012; Monteiro and Feng, 2017), we first subjected Emx1-Cre; Shank3Δ14–16 mice to behavioral tests in the social domain. The gene discussed is SHANK3; the disease is neurodevelopmental disorder.