It has been suggested that TREM2-dependent microglial functions limit amyloid plaques growth early by promoting Aβ phagocytosis but not late during the disease by increasing the levels of APOE around amyloid deposits, hence promoting further Aβ aggregation (Parhizkar et al., 2019) given the known role of APOE on Aβ deposition. Here, APOE is linked to amyloidosis.