Expression of the AD-associated R47H variant and Nasu-Hakola disease (NHD)-associated TREM2 mutants Y38C also strongly reduced the phagocytic activity of TREM2 in HEK293 cells (Figure 1E) mimicking previous observations in microglial cells expressing TREM2 mutations (Kleinberger et al., 2014). The gene discussed is TREM2; the disease is Alzheimer disease.