MAPT and Alzheimer disease: The brain of Alzheimer’s disease (AD) patients is characterized by the presence of three pathologies that are central to the AD process: extracellular accumulation of cerebral β-amyloid (Aβ); intraneuronal accumulation of hyperphosphorylated and aggregated tau, and; inflammation (Hardy and Selkoe, 2002; De Strooper and Karran, 2016; Hammond et al., 2019).