TREM2 and Alzheimer disease: Aβ oligomers have also been shown to interact with TREM2 with high affinity and to induce NFAT (nuclear factor of activated T cell) signaling while in TREM2 AD variants, although the Aβ affinity for TREM2 remains unchanged, NFAT signaling induced by Aβ oligomers is reduced suggesting a partial loss of TREM2 function (Lessard et al., 2018).