CALB1 and Lewy body dementia: Furthermore, a study in human brain tissues from dementia with Lewy bodies (DLB) patients showed that the Lewy bodies were exclusively formed in calbindin-negative neurons, a result that was confirmed using the mouse rotenone model, where α-syn aggregation was evident primarily in calbindin-negative neurons (Rcom-H’cheo-Gauthier et al., 2016).