ZIC2 and cancer: Zinc-finger protein of the cerebellum (ZIC) 2, identified as a target gene of miR-129-5p in the present study, is the vertebrate homologues of the Drosophila odd-paired (OPA) gene, including ZIC1, ZIC2, ZIC3, ZIC4 and ZIC5, and has been implicated in multiple diseases including cancer [15, 16].