TNC and cancer: For instance, the TNC-integrin α5β1 interaction was shown to block cell adhesion, stimulate tumour cell proliferation,40 regulate the chemotaxis of human monocytes and polymorphonuclear leucocytes,41 inhibit fibroblast cell cycle progression,42 protects cancer stem-like cells from immune surveillance,43 and enhance cell survival and proliferation in a platelet-derived growth factor-dependent way.44 We further discovered decreased phosphorylation of Src (but not FAK) induced by knockout of TNC and that YAP cytoplasmic retention was driven by an Src inhibitor.