MYC, which was reported to be a transcriptional target of YAP in both gastric cancer and osteosarcoma,51,52 can transcriptionally activate MALAT1 by directly binding to the MALAT1 promoter region.36 These results indicate that MYC may be partly responsible for YAP-mediated MALAT1 activation. The gene discussed is MALAT1; the disease is osteosarcoma.