Among these integrins, integrin α5β1 is one of the most significant members of the integrin family that influences tumour survival, proliferation, migration, and chemo-resistance.37–39 TNC was reported to regulate various cell behaviours by interacting with integrin α5β1 in both a syndecan-4-dependent and syndecan-4-independent manner. The gene discussed is SDC4; the disease is neoplasm.