MALAT1 and Ewing sarcoma: Dephosphorylated YAP further activates itself and translocates to the nucleus by negatively regulating Hippo signalling.35 Activated YAP also transcriptionally activates MALAT1 by binding to a region of the MALAT1 promoter,17,28 and this enhanced MALAT1 expression may trigger the expression of downstream genes to positively regulate ES tumour progression.36 Consistently, in our study, MALAT1 expression was significantly decreased by the pharmacological inhibition of YAP with verteporfin.