ECM proteins are pivotal in regulating tumorigenesis and progression in most tumour types through matrix-cell interactions.15 TNC is one of the most prominent ECM proteins, and the overexpression of TNC is associated with many aspects of tumour cell behaviours in various tumours.8 However, the regulatory role of TNC and the underlying mechanism of this role in ES remain obscure. This evidence concerns the gene TNC and neoplasm.