TNC and cancer: Indeed, integrin α5β1-Src signalling plays a crucial role in different cancer types,45–47 and activated Src is capable of inducing YAP dephosphorylation and nuclear accumulation to regulate the downstream target gene expression.48–50 These results indicate that activated Src, but not FAK, may be partially responsible for TNC/integrin α5β1-mediated YAP activation in ES.