For instance, the TNC-integrin α5β1 interaction was shown to block cell adhesion, stimulate tumour cell proliferation,40 regulate the chemotaxis of human monocytes and polymorphonuclear leucocytes,41 inhibit fibroblast cell cycle progression,42 protects cancer stem-like cells from immune surveillance,43 and enhance cell survival and proliferation in a platelet-derived growth factor-dependent way.44 We further discovered decreased phosphorylation of Src (but not FAK) induced by knockout of TNC and that YAP cytoplasmic retention was driven by an Src inhibitor. The gene discussed is PTK2; the disease is cancer.