To further validate the role of L-MPs in lung cancer patients, we used a humanized mouse model.26 After 9 weeks of human hematopoietic stem cell (HSC) transplantation, we identified humanized mice in which 90% of the bone marrow cells were positive for human CD45 (Fig. 7f, Supplementary Fig. 14). The gene discussed is PTPRC; the disease is lung cancer.