HSP90B2P and melanoma: This non-linear dependence of apoptotic cellular response on the thermal pulse amplitude may be explained by sensitivity of the melanoma cells to the properties of thermal pulses (e.g. duration, amplitude, period, temperature rise rate, and fast on/off temperature change) and/or by existence of a threshold in the capacity of cells to respond to thermal stress, such as limits in HSP regulation (see next sub-section).