Discovery of eight novel loci significantly associated with UL reveals several candidate genes of particular interest: BABAM2, FSHB, HMGA1, and WNT2. Because UL are benign tumors that rarely, if ever, develop into malignancy, the association between UL and multiple loci harboring well-known oncogenes and tumor suppressor genes is also worthy of note. This evidence concerns the gene WNT2 and uterine corpus leiomyoma.