MYC and ovarian cancer: On the basis of a previous study on the role of ACTL6A in c-Myc oncogenic activity36, we determined that ACTL6A interacted with c-Myc in ovarian cancer cell OVCAR-3, but not PGK1 (Supplementary Fig. S3c); the silencing of c-Myc significantly inhibited ACTL6A-induced PGK1 (Fig. 3f and Supplementary Fig. S3d).