More importantly, it was found that Wnt/β-catenin signaling inhibitor could reverse the accelerative effect of LDLRAD2 overexpression on the in vitro migration and invasion of GC cells, while Δ-β-catenin could reverse the inhibitory effect of LDLRAD2 downregulation on the in vitro migration and invasion of GC cells. Here, LDLRAD2 is linked to gastric cancer.