Albeit in this study we did not explore the effect of inhibition of EMT on LDLRAD2/Wnt/β-catenin signaling axis-induced invasion and metastasis of GC cells, we may deduce that LDLRAD2 activates Wnt/β-catenin to induce EMT, thereby promoting invasion and metastasis of GC cells. Here, LDLRAD2 is linked to gastric cancer.