Using this approach, a total of 6 prohormones were found to correlate with migraine and/or OIH conditions from their respective controls: Vasoactive Intestinal peptide (VIP), PACAP, thyrotropin-releasing hormone prohormone (proTRH), PENK, SCG and proSAAS (Fig. 4C). The gene discussed is PCSK1N; the disease is migraine disorder.