Interestingly, seven of the peptides (Migraine: DH-SCGI [356–374](P16014) and PAG - PENK A[197–208](P22005); OIH: NAc - AN32A [1–11](O35381); PAG - proSAAS [45–59](Q9QXV0), SCG[437–454](P16014); DH- TKN[101–107] (P41539) and TN-SCG [333–355](P16014)) with significantly altered levels between migraine/migraine control and OIH/OIH control groups showed differences in the opposite direction between the two cohorts measured. The gene discussed is PCSK1N; the disease is migraine disorder.