PENK and migraine disorder: Specifically, for migraine: VIP and SCG2 in the NAc, PACAP, SCG1, and proTRH in the PAG, and PENK in the DH; and for OIH: VIP in the NAc, SCG, proSAAS and PACAP in the PAG, and SCG in the TN and DH, were significantly changed between the treated and control groups (p ≤ 0.1) in both cohorts (supplemental Table S3 and Fig. 4B).