Another more recent study has found that Survivin was expressed in SS patients' Sézary cells but not in healthy donors' CD4+ T cells, and that Avicin-D-induced apoptosis in these cells was partially dependent on downregulation of STAT-3 and the anti- apoptotic proteins (BCL2 and Survivin) [32]. The gene discussed is BCL2; the disease is synovial sarcoma.