To better characterize the pharmacologic potential of FND-4b as a novel chemotherapeutic agent, we investigated the effect of FND-4b, either alone or in combination with PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase (PI3K) and mTOR [14–18], or SN-38, the active metabolite of the topoisomerase inhibitor irinotecan [19], on cell cycle arrest and apoptosis of commercially-available human CRC cell lines. The gene discussed is MTOR; the disease is colorectal carcinoma.