The obetd15 mutation is c.502T > C, p.Phe168Leu, located within the M2 domain coding region (Fig. 1c); when the human and zebrafish Kir7.1 protein sequences are aligned, the amino acid changes carried by the obetd15 fish and LCA patients are separated by two residues. Here, KCNJ13 is linked to Leber congenital amaurosis.