The CTSG N125S AG heterozygous genotype was significantly more frequent among osteomyelitis patients compared to controls (15.5% vs. 9.4%; χ2 = 6.5, OR = 1.78, 95% CI = 1.11–2.84, p = 0.011 by the Mantel-Haenszel test, χ2 = 5.95, p = 0.014 by the Yates correction). The gene discussed is CTSG; the disease is osteomyelitis.