Our findings that GLO1 levels are reduced in induced astrocytes derived from ALS and Parkinson’s patients are interesting especially in light of the recent findings that Nrf-2, a key regulator of oxidative stress that is normally sequestered and inactivated by the Kelch-like ECH associated protein 1 (KEAP1), is released and activated by accumulation of methylglyoxal (Bollong et al., 2018). Here, KEAP1 is linked to amyotrophic lateral sclerosis.