Previous studies have reported that the PPP2R3A subtype PR130 can redistribute SHIP2 (SH2 domain‐containing phosphatidylinositol‐3,4,5‐trisphosphate 5‐phosphatase) to the cell membrane to prevent EGF‐induced EGFR degradation.19 Therefore, the cytoplasm and membrane may be the sites of the biological function of PPP2R3A in liver cancer. Here, EGF is linked to liver cancer.