In view of lnc‐ITSN1‐2, although there are three previous studies elucidating the potential of lnc‐ITSN1‐2 for the disease risk of inflammation‐related diseases (including RA, sepsis, and CAD), no previous study has been carried out to explore the role of lnc‐ITSN1‐2 in AIS until now. Here, ITSN1 is linked to coronary artery disorder.