Although some proinflammatory factors or neutrophil-attracting factors, such as MMP3, CCL5, leptin and VEGF-A, were decreased in the IT-101-treated group, other factors like sCD30, sCD30L, sCD40 and sCD40L (that are reported inflammatory markers in cancer patients), were elevated in the circulation of IT-101-treated mice. The gene discussed is CD40LG; the disease is cancer.