Our data indicated that patients with high HER2 protein expression/ gene amplification and null GSTM1 genotype had significant poor survival compared to patients with low HER2 expression and null GSTM1 genotype, suggesting that combining HER2 status with GSTM1 genotype may have a prognostic value for bladder cancer patients. This evidence concerns the gene ERBB2 and urinary bladder cancer.