Autonomic disturbance [21], release of calcitonin-gene related peptide at dural vessels with subsequent neurogenic inflammation [22], release of vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide by parasympathetic fibres innervating the dura mater [23] are also considered in migraine pathogenesis. The gene discussed is VIP; the disease is migraine disorder.