Furthermore, significantly increased risk for preeclampsia was found with MTHFR: c.665C > T, in dominant (CT/TT versus CC: OR = 2.91, 95% CI = 1.29–6.57; P* = 0.0497), overdominant (CT versus CC/TT: OR = 2.79, 95% CI = 1.18–6.59; P* = 0.046) and log-additive (OR = 2.48, 95% CI = 1.20–5.13; P* = 0.0396) models. The gene discussed is MTHFR; the disease is preeclampsia.