Ubiquitin‐conjugating enzyme E2C (UBE2C), working closely with anaphase‐promoting complex/cyclosome (APC/C), is one of the important enzymes for ubiquitination.4 The aberrantly high expression of UBE2C may result in tumorigenesis and potentially be a prognostic biomarker for cancer.5 The elevated expression of UBE2C was detected in various human solid cancers, such as colon,6 lung,7 liver,8 breast,9 and thyroid.10 Furthermore, overexpression of UBE2C was also found in PCa,11, 12 especially in castration‐resistant PCa (CRPC).13, 14 However, the role of UBE2C in CRPC still remains unclear. The gene discussed is UBE2C; the disease is cancer.