MiRNAs can act as either tumor suppressor genes or oncogenes depending on the target mRNAs in various tumor types, including PCa.17 For instance, miR‐16 inhibits the growth of metastatic PCa via downregulating multiple cell cycle genes whereas miR‐141 and miR‐375 enhance the PCa progression.18, 19 Furthermore, Zhang et al20 demonstrated that miR‐381 functioned as a tumor suppressor microRNA in rectal carcinoma through specific inhibition of UBE2C expression. This evidence concerns the gene UBE2C and posterior cortical atrophy.