VEGFA and cancer: In this study, we identified that cancer cell-derived sEVs can stimulate endothelial cell migration and tube formation independently of uptake, and that these responses are mediated by the 189 amino acid, heparin-bound isoform of vascular endothelial growth factor (VEGF) that, unlike other common isoforms of VEGF, is enriched on the surface of sEVs.