In addition to the protective effect of iguratimod on bone resorption during RA, its role in osteoporosis has also been investigated in postmenopausal patients by Wu et al.62 They created an osteoporosis model in ovariectomized mice and isolated bone marrow mononuclear cells that were induced to differentiate into osteoclasts with RANKL. Here, TNFSF11 is linked to rheumatoid arthritis.