Cachexia is one of the conditions most commonly associated with cancer97,98 and autoimmune diseases, i.e., RA characterized by wasting, weakness, and anorexia.99 In adenocarcinoma-induced cachexic mice, the iguratimod effect was evaluated by Tanaka et al.100 They found that iguratimod reduced the IL-6 serum level by suppressing its mRNA level, which resulted in inhibition of muscle wasting (gastrocnemius) and loss of adipose tissue (epididymis). This evidence concerns the gene IL6 and rheumatoid arthritis.