IL6 and rheumatoid arthritis: It has an anabolic effect on the bone metabolism of the infected joint by osteoclastogenesis inhibition and osteoblast differentiation.16 Moreover, its downregulatory effect on serum IL-6 levels17 provides an edge over conventional NSAIDs, currently in vogue for RA treatment, e.g., nimesulide.18 It has also been reported to have lower gastrointestinal ulcerogenic properties, which is the main concern of clinicians regarding NSAIDs that inhibit cyclooxygenase-1 (COX-1) to reduce inflammation.