Rendina et al.210 found that women with AA rs6166 (FSHR) had a higher postmenopausal osteoporosis risk than those carrying the GG rs6166 variant, and Ferlin et al.210 found that young men with a T222P mutation in RXFP2 were at high risk of osteoporosis, while Liu et al.212 suggested that an SNP (C-to-G substitution at codon 727) in TSHR may be an osteoporosis risk factor. This evidence concerns the gene RXFP2 and osteoporosis.