Mutation of LHCGR207–209 was associated with reduced human height; FSHR,210RXFP2,211 and TSHR212 mutations were associated with human osteoporosis; OR2H1 was associated with human OA213; FSHR,210LGR4,214RXFP2,215 and TSHR216 were associated with reduced human BMD, and FPR mutation was associated with juvenile periodontitis (Table 5). Here, FSHR is linked to osteoporosis.