DRD2 polymorphism could influence human height in childhood, acting through the hypothalamus (growth hormone (GH)-releasing hormone)–pituitary (GH)–Insulin-like growth factor 1 (IFG-1) axis,22 while MTNR1B polymorphism was associated with adolescent idiopathic scoliosis (AIS). This evidence concerns the gene GH1 and adolescent idiopathic scoliosis.