The mutation of GPR126 was associated with alterations in AIS,248,250–253 human height,253–257 arthrogryposis multiplex congenital,258 and aggressive periodontitis.259 Xu et al.252 found that three intronic SNPs of GPR126 (rs6570507, rs7774095, and rs7755109) were significantly associated with AIS in Chinese populations, and Kou et al.253 also found that rs6570507 was the most significantly linked SNP to AIS in Japanese and European ancestry populations. This evidence concerns the gene ADGRG6 and periodontitis.