NAGLU and mucopolysaccharidosis type 3B: NAGLU gene code for a lysosomal enzyme called Alpha-N-acetylglucosaminidase (1) This gene encoded for as N-acetyl glucose amine, have been previously reported to cause mucopolysaccharidosis IIIB (MPS IIIB) (19) found at the cell surface and extracellular matrix binds to a variety of protein ligands and regulates a wide range of biological roles in key developmental signaling pathways.