Furthermore, three human AML cell lines (HL-60, THP-1 and KG-1) with higher RPPH1 expression had markedly reduced expression of miR-330-5p when compared with the control HS-5 cells (Figure 3D(Fig. 3)), which further confirmed that miR-330-5p is a target of RPPH1. The gene discussed is RPPH1; the disease is acute myeloid leukemia.