In particular, eight significantly mutated putative TSGs found previously in an independent dataset24 were also found in our analyses, including GPS2 (pan-cancer, breast), SOX9 (pan-cancer, colorectal), TGIF1 (pan-cancer, colorectal), ZFP36L1 (pan-cancer, urinary tract) and ZFP36L2 (pan-cancer, colorectal), HLA-B (lymphoid), MGA (pan-cancer), KMT2B (skin) and RARG (urinary tract). The gene discussed is RARG; the disease is cancer.