Although most of these relationships are well established, in breast cancer, we found new positive relationship for GATA3–VMP1 (q = 6 × 10−5) and FOXA1–PIK3CA (q = 3 × 10−3), and negative relationships for ESR1–TP53 (q = 9 × 10−4) and GATA3–TP53 (q = 5 × 10−5). The gene discussed is ESR1; the disease is breast cancer.