HMGB1 and Hepatic fibrosis: When using this list for an Ingenuity Pathway Analysis (IPA), “HMGB1 pathway” (p = 9.26 × 10−10) followed by “Hepatic fibrosis/Stellate cell activation” (2.68 × 10−09) was suggested as the two top canonical pathways associated with the RETN polymorphism (Table 3).