A 32-yr-old Caucasian male with XP complementation group C (compound heterozygous mutations; c.445_446delGA in exon 4a and c.2336 del T in exon 13 in XPC) (XP1SH) presented in January 2017 with a rapidly growing violaceous nodule on the left supraorbital area (Fig. 1). The gene discussed is XPC; the disease is xeroderma pigmentosum.