IL33 and Pruritus: We show that JunBΔep skin has infiltration of Ym1-positive cells (Figure 1B), increased TSLP and IL-33 levels in skin (Figures 1C and 1D), elevated serum IgE (Pflegerl et al., 2009) (Figure 1E), and significant pruritus (Figure 1F), all important hallmarks of type 2 inflammation and AD (Welch et al., 2002, Nair et al., 2003, Bird, 2005, Cevikbas and Steinhoff, 2012, Doherty et al., 2013, Wilson et al., 2013, Turner and Zhou, 2014).