We show that JunBΔep skin has infiltration of Ym1-positive cells (Figure 1B), increased TSLP and IL-33 levels in skin (Figures 1C and 1D), elevated serum IgE (Pflegerl et al., 2009) (Figure 1E), and significant pruritus (Figure 1F), all important hallmarks of type 2 inflammation and AD (Welch et al., 2002, Nair et al., 2003, Bird, 2005, Cevikbas and Steinhoff, 2012, Doherty et al., 2013, Wilson et al., 2013, Turner and Zhou, 2014). This evidence concerns the gene IL33 and Alzheimer disease.