Furthermore, group 2 innate lymphoid cells (ILC2s), which produce IL-13 and have been proposed to contribute to the pathogenesis of AD (Kim et al., 2013, Roediger et al., 2013, Salimi et al., 2013), were also increased before epidermal hyperplasia, but their numbers normalized as inflammation worsened (Figure 3C). This evidence concerns the gene IL13 and Alzheimer disease.