The action of Akt protein, previously mentioned as an important mediator of GLUT4 mobilization from GLUT4-containing vesicles to the membrane, may be impaired by the mammalian homolog of Ddosophila tribbles TRB3, whose expression is increased in obesity.106 However, PE seems to be able to reduce the expression of this protein TRB3. The gene discussed is SLC2A4; the disease is Obesity.