The action of Akt protein, previously mentioned as an important mediator of GLUT4 mobilization from GLUT4-containing vesicles to the membrane, may be impaired by the mammalian homolog of Ddosophila tribbles TRB3, whose expression is increased in obesity.106 However, PE seems to be able to reduce the expression of this protein TRB3. This evidence concerns the gene SLC2A4 and obesity due to melanocortin 4 receptor deficiency.