Regarding AMPK in DM2 and IR scenario, many studies have suggested that muscle contraction plays a central role, regardless of insulinemic status, where the activity of AMPK-α2 in skeletal muscle in response to PE was similar to that in individuals without DM2, indicating a normal functioning of muscle AMPK in diabetics, which is particularly important in IR conditions.104 In another study, an acute bout of aerobic exercise (one hour duration) at 75% of VO2max did not increase insulin sensitivity in obese diabetic subjects. Here, PRKAA2 is linked to diabetes mellitus.