There was a significant associationbetween MMP-7 -181A>G polymorphism and GC risk under the homozygote model(GG vs. AA: OR=1.672, 95% CI 1.161-2.409, p=0.006) and the recessive model(GG vs. GA+AA: OR=1.672, 95% CI 1.319-2.554, p=0.001), but not with CRC. Here, MMP7 is linked to colorectal carcinoma.