We also performed subgroup analyses based on the source of control and genotypingmethod, when it was available (Table 3).The hospital-based subgroup analysis revealed that the presence of the MMP-7-181A>G polymorphism was related to a higher risk of CRC under the homozygotemodel (GG vs. AA: OR=0.671, 95% CI 0.484-0.951, p=0.023). The gene discussed is MMP7; the disease is colorectal carcinoma.