Similarly, Yang et al in a meta-analysis of seven studies with 1,502 CRCcases and 1,602 controls found significant association between MMP-7 -181A>Gpolymorphism and CRC under the homozygote model (OR=1.31, 95% CI 1.02-1.69) .31 Here, MMP7 is linked to colorectal carcinoma.