Elevated concentrations of imputed AAT were associated with increased 8-year risk from a wide range of disease classifications, including liver diseases (Hazard Ratio = 1.81 per standard deviation increase in AAT, 95% Confidence Interval = 1.46–2.25, False Discovery Rate adjusted P-value = 1×10−6), heart failure (HR = 1.60, 95% CI = 1.41–1.82, FDR = 1×10-10), and chronic obstructive pulmonary disease (HR = 1.54, 95% CI = 1.34–1.77, FDR = 3×10−8) (full list given in Fig 3). This evidence concerns the gene SERPINA1 and heart failure.