In contrast, imputed AGP was significantly associated with increased risk from only two outcomes: heart failure (HR = 1.56, 95% CI = 1.35–1.81, FDR = 1×10−6) and chronic lower respiratory diseases (HR = 1.31, 95% CI = 1.19–1.43, FDR = 2×10−6) (Fig 3). The gene discussed is ATP5MK; the disease is lower respiratory tract disorder.