LPL and coronary artery disorder: Additionally, pre-heparin serum LPL has been shown to be inversely related to the progression of coronary artery disease in young/middle–older aged populations (Hitsumoto, Ohsawa [42]: 22–79 years, Rip, Nierman [43]: 45–79 years), highlighting that pre-heparin serum LPL is anti-atherogenic.