CD274 and infection: As shown in Fig 6, infection of either viR-138-5p MVA or viR-193a-3p MVA induced a significant decrease in the number of cells expressing PD-L1 in both cell lines tested as compared to control viRNA containing scramble siRNA (viR-scramble) or sucrose purified liposomes complexed with miR-138-5p (as a negative control, NC).