As a minor histocompatibility antigen, UTY is a well-known contributor to the regulation of immune response.48 It also emerges that UTY may be involved in host response to viral infections through contributions to antigen processing and presentation.49 To this end, the dominance of immunity in the overlap between haplogroup I1–associated and UTY-related pathways is perhaps not surprising. This evidence concerns the gene UTY and viral infectious disease.