Compared with early stage breast cancer, women with ER‐, PR‐, HER2+, and high expression of Ki‐67 (≥14%) had increased odds of advanced stage breast cancer, consistent with the previous reports indicating worse clinical outcomes for these immunohistochemical categories.41, 42, 43 The association between primary tumor location and patient's prognosis has been evaluated previously for progression of breast cancer.44, 45, 46, 47, 48 In our study, we found that breast tumors located in the UOQ and LIQ tended to be advanced stage breast cancer. The gene discussed is ESR1; the disease is breast carcinoma.