IL6 and Familial prostate cancer: High levels of ERα expression in CAFs inhibited the invasion and migration of prostate cancer by affecting TAM infiltration in vitro and in vivo.54 ERα decreased the expression of chemokine (C‐C motif) ligand 5 (CCL5) and IL‐6 in CAFs and macrophages that were co‐cultured with CAFs in conditioned medium.