Matthew et al found that CAFs activated an immune checkpoint to suppress the function of T cells, which was mediated by the engagement of PDL2 and FASL Therefore, CAFs contribute to the suppression of anti‐tumour T cell response by regulating immune cells, such as promoting antigen‐specific T cells death.85 Cancer‐associated fibroblasts can also promote the invasion and metastasis of tumour cells. This evidence concerns the gene PDCD1LG2 and neoplasm.