Some studies reported that accumulation of macrophages in TME correlated with poor prognosis of patients.45, 46 Mazur et al reported that type I collagen cleaved by FAP from activated fibroblasts, a post‐prolyl peptidase, could act as the substrate of macrophages which recognized by macrophages class A scavenger receptors (SR‐A); therefore, it increased the macrophages adhesion in cancer.47 Tumour‐associated macrophages (TAMs) consist of two groups with different phenotypes. This evidence concerns the gene FAP and cancer.