ACTA1 and neoplasm: Once the would heals, the number of activated fibroblasts decreases dramatically.15 Compared to the quiescent fibroblasts, activated fibroblasts could express de novo α‐smooth muscle actin (α‐SMA), increase the production of proinflammatory cytokines and cyclooxygenase‐2 (COX‐2), which further mediated the inflammatory response and tumour progression.16 In the permanent activation state, fibroblasts promote the growth and progression of tumours, which can affect the behaviour of tumours and patient prognosis.17