However, a low concentration of curcumin had few effects on the proliferation of CAFs but decreased the expression of α‐SMA and vimentin, suggesting that curcumin at low concentrations can reverse the activation of fibroblasts.97 Conditioned medium with CAFs increased the migration and invasion ability of pancreatic cancer cells, and conditioned medium with curcumin‐treated CAFs had minimal effects on the migration ability of pancreatic cells.97 Prostate cancer cells were treated with CAF‐conditioned medium and flavonoid silibinin‐conditioned medium. The gene discussed is ACTA1; the disease is pancreatic neoplasm.