Liao et al showed that FAP was specifically overexpressed in the fibroblasts in the tumour stroma.84 CD8+ T cells could exert cytotoxic effect to the tumour via targeting the FAP antigen in the CAFs.103 Therefore, these studies showed that the targeting CAFs via FAP antigen can inhibit tumour growth and progression, which possibly mediated by T cell immunotherapy.33 A DNA vaccine that targeted the tumour matrix antigen FAPα induced an anti‐tumour immune response that was mainly mediated by CD8+ T cells.104. The gene discussed is CD8A; the disease is neoplasm.