Fibroblasts that were activated by macrophages dynamically stimulated prostatic cancer, which were mediated by IL‐6 and SDF‐1.53 Zhang et al found that in a co‐culture with macrophages, MSCs that were derived from the human umbilical cord differentiated into CAFs, and promoted gastric epithelium cell malignancy via epithelial–mesenchymal transition (EMT).56 However, research that has focused on the influence of macrophages on CAFs has been very limited, and further studies are needed. Here, CXCL12 is linked to Familial prostate cancer.