Lee et al showed that WA promoted TRAIL‐induced apoptosis of the human renal cancer cells (Caki) through up‐regulation of death receptor 5 and down‐regulation of c‐FLIP.25 Hahm et al indicated that WA activated Bax and Bak to induce the apoptosis of MDA‐MB‐231 and MCF‐7 cells.14 Stan et al addressed the mechanism by which WA caused Bim‐dependent apoptosis.26 Our results showed that WA induced apoptosis of GBM cells by the intrinsic rather than the extrinsic pathway (Figure 1). The gene discussed is TNFRSF10B; the disease is renal carcinoma.