CEACAM5 and squamous cell lung carcinoma: In a recent study involving 224 patients, Wang et al. [112] evaluated the prognostic significance of serum tumour markers (CYFRA 21-1, CEA and NSE) in locally advanced squamous cell carcinoma of lung (LA-SCCL) after radiotherapy and found that increased NSE predicted poor distant metastasis-free survival (DMFS).