Pooled sensitivity of NSE for detecting SCLC was 0.688 (95% CI: 0.627–0.743), specificity was 0.921 (95% CI: 0.890–0.944), positive likelihood ratio was 8.744 (95% CI: 6.308–12.121), negative likelihood ratio was 0.339 (95% CI: 0.283–0.405). Here, ENO2 is linked to small cell lung carcinoma.