EIF4EBP1 and Familial prostate cancer: 2007). mLST8 upregulation could promote phosphorylation of 4E-BP1, which is known to play a role in tumor progression in various cancers including breast, ovarian, and prostate cancers (Armengol et al. 2007). Thus, we hypothesized that mLST8 is essential for tumor progression. A recent study focused on the relationship between SNPs of mLST8 and gastric cancer showed that although mLST8:rs26865 was not statistically related to gastric cancer, its hazard ratio of > 1 suggests a tendency to promote gastric cancer (Xue et al. 2018).