We found that rs26865 and rs3160 polymorphic variants of mLST8 were significantly associated with the risk of BM, particularly among those with lymph node metastasis (N2/3), high CEA and SCC antigen level, and high Ki-67 proliferation index and gene mutation frequency. Here, SERPINB3 is linked to metastatic malignant neoplasm in the lymph nodes.