Manual searching of the list of up-regulated proteins identified several of relevance to atopic eczema, including: STAT1, an intracellular signalling molecule that shows increased expression in atopic eczema, and as part of the JAK-STAT pathway is targeted by several traditional herbal remedies44 as well as novel small molecule therapies45; carbonic anhydrase 2, which is increased in skin in a variety of forms of eczema46; and FK binding protein, which binds to tacrolimus, an established topical treatment for atopic eczema. Here, CA2 is linked to atopic eczema.