For instance, in a long time-course study of IFNγ activation of melanoma cells, 4 of the 10 highest regulated miRNAs were ‘star’ strands (miR-424-3p, miR-29b-1-5p, miR-27a-5p and miR23a-5p; current miRbase annotations), that were induced where the partner strands were not45. This evidence concerns the gene IFNG and melanoma.