Based on these findings, we hypothesized that epithelial-derived cytokines may contribute to develop type 2 airway inflammation in the development of WRS in bakery workers and evaluated the levels of serum TGF-β1, eosinophil-derived neurotoxins (EDN), and eotaxin-2 in wheat flour-exposed workers in order to further understand its pathogenic mechanisms. The gene discussed is RNASE2; the disease is Wolcott-Rallison syndrome.