Hence, cytokines such as IL-2 and IFN-γ secreted by CD4+ T cells during HIV infection are expected to be low whereas an upregulation in the production of T helper 2 (Th2) cytokines such as IL-4 and IL-10 and proinflammatory cytokines such as IL-1, 6, and 8 is expected [17]. This evidence concerns the gene CD4 and HIV infectious disease.