CDH1 and colorectal carcinoma: Subsequently, free cytosolic β-catenin is translocated to the nucleus where it binds to the transcription factor TCF4 inducing WNT target gene transcription including activation of E-cadherin repressors ZEB1 and SNAI1 and upregulation of MT1-MMP9 and LAMC2 that are associated with CRC invasiveness [31, 44].