CD274 and neoplasm: According to the tumor immunity in the microenvironment (TIME) classification [1], tumors can be divided into 4 subgroups based on the presence of inflammatory infiltrate (TIL) and PD-L1 expression: T1 (PD-L1−, TIL−), T2 (PD-L1+, TIL+), T3 (PD-L1−, TIL+), and T4 (PD-L1+, TIL−) (Figure 1).