We did not find evidence that a similar mechanism is active in adult hearts after long-term LPD treatment, as we did not detect differences in eIF2α phosphorylation (Fig. 7a) or RNA expression of ATF4 and AASR target genes (Fig. 7b) between SPD and LPD hearts. This evidence concerns the gene EIF2A and disseminated peritoneal leiomyomatosis.